Abstract
This study examined the role of dorsal hippocampal NMDA receptors and PKA activation in 17 beta-estradiol (E2)-induced enhancement of object memory consolidation. Mice explored two identical objects during training, after which they immediately received intraperitoneal injections of 0.2 mg/kg E2, and bilateral dorsal hippocampal infusions of Vehicle, the NMDA receptor antagonist APV (2.5 microg/side), or the cAMP inhibitor Rp-cAMPS (18.0 microg/side). Retention was tested 48 hours later. The enhanced object memory and increased ERK phosphorylation observed with E2 alone was reduced by APV and Rp-cAMPS, suggesting that estrogenic enhancement of object memory involves NMDA receptors and PKA activation within the dorsal hippocampus.
(Copyright) 2008 APA, all rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Behavior, Animal / drug effects
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Cyclic AMP / analogs & derivatives
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Cyclic AMP / pharmacology
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Cyclic AMP-Dependent Protein Kinases / physiology*
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Drug Interactions
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Estradiol / pharmacology*
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Estrogens / pharmacology*
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Excitatory Amino Acid Antagonists / pharmacology
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Extracellular Signal-Regulated MAP Kinases / metabolism
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Female
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Hippocampus / drug effects*
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Memory / drug effects*
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Mice
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Mice, Inbred C57BL
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Ovariectomy
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Pattern Recognition, Visual / drug effects*
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Photic Stimulation / methods
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Protein Kinase Inhibitors / pharmacology
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Receptors, N-Methyl-D-Aspartate / physiology*
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Thionucleotides / pharmacology
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Estrogens
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Excitatory Amino Acid Antagonists
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Protein Kinase Inhibitors
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Receptors, N-Methyl-D-Aspartate
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Thionucleotides
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adenosine-3',5'-cyclic phosphorothioate
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Estradiol
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2-amino-5-phosphopentanoic acid
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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Extracellular Signal-Regulated MAP Kinases
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Valine