Dense serotonergic innervation of principal nuclei of the superior olivary complex in mouse

Ann M Thompson; Laura M Hurley

doi:10.1016/j.neulet.2003.11.052

Dense serotonergic innervation of principal nuclei of the superior olivary complex in mouse

Neurosci Lett. 2004 Feb 19;356(3):179-82. doi: 10.1016/j.neulet.2003.11.052.

Authors

Ann M Thompson¹, Laura M Hurley

Affiliation

¹ Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA. ann-thompson@ouhsc.edu

PMID: 15036624
DOI: 10.1016/j.neulet.2003.11.052

Abstract

To evaluate species differences in the serotonergic innervation of the superior olivary complex, serotonergic fibers and varicosities were labeled with immunohistochemistry in mouse. Many immunoreactive fibers and varicosities were observed in two of the three principal nuclei, in addition to some periolivary nuclei. This pattern of staining differs greatly from that observed in other mammals in which periolivary, but not principal nuclei are richly innervated by serotonin (5-HT). These results indicate a functional relationship between the 5-HT system and both the ascending and descending auditory systems in the mouse.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Count
Cell Nucleus
Evoked Potentials, Auditory, Brain Stem / physiology
Immunohistochemistry / methods
Mice
Mice, Inbred Strains
Olivary Nucleus / cytology
Olivary Nucleus / metabolism*
Presynaptic Terminals / physiology
Serotonin / metabolism*
Staining and Labeling

Substances

Serotonin