Two experiments investigated the effects of ovariectomy and estradiol replacement on the body weight and food intake of mice that had previously been treated with either gold thioglucose or saline. Ovariectomy and estradiol benzoate injections altered food intake in gold thioglucose-treated mice as much as in saline controls. Ovariectomy increased body weight in saline controls but it was without effect on the body weight of gold thioglucose-treated mice.