Abstract
Diverse K(+) channels exhibit differential expression and function in human lymphocytes. Voltage-gated and Ca(2+)-activated K(+) channels have a significant impact on both T-cell activation and the overall immune response. A recent study on the plasma membrane organization of Kv1.3 K(+) channels in human T cells provides new insights into the immunoregulatory functions of K(+) channels, which might result in new and improved immune suppression protocols targeted to ion channels and/or T-cell signaling and accessory molecules.
MeSH terms
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Adjuvants, Immunologic / pharmacology
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Calcium / physiology
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Calcium Channel Blockers / pharmacology
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Cell Division
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Humans
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Intermediate-Conductance Calcium-Activated Potassium Channels
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Ion Channel Gating
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Kv1.3 Potassium Channel
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Lymphocyte Activation
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Potassium Channels / drug effects
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Potassium Channels / immunology*
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Potassium Channels / physiology
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Potassium Channels, Voltage-Gated*
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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T-Lymphocytes / physiology
Substances
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Adjuvants, Immunologic
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Calcium Channel Blockers
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Intermediate-Conductance Calcium-Activated Potassium Channels
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KCNA3 protein, human
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KCNN4 protein, human
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Kv1.3 Potassium Channel
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Potassium Channels
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Potassium Channels, Voltage-Gated
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Calcium