Abstract
This review focuses on the properties and roles of distinct subsets among the primary and the memory B lymphocytes regarding their contribution to helper-T-cell-dependent and -independent antibody responses. The naive/memory B cell functions are explained in the context of current concepts on the basic mechanisms of humoral immunity. Differences between murine and human B cells are also discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antibody Formation
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Antigen Presentation / immunology
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Antigens, T-Independent / immunology
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B-Cell Activating Factor
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B-Lymphocyte Subsets / immunology*
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Calcium Signaling
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Cell Division
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Dendritic Cells / immunology
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Germinal Center / immunology
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Hematopoietic Stem Cells / cytology
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Humans
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Immune Tolerance
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Immunity, Innate
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Immunization
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Immunoglobulin Class Switching
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Immunologic Memory / immunology*
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Lymphocyte Activation
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Membrane Proteins / physiology
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Mice
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Plasma Cells / immunology
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Receptors, Antigen, B-Cell / immunology
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Sheep
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Somatic Hypermutation, Immunoglobulin
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T-Lymphocyte Subsets / immunology*
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Tumor Necrosis Factor Receptor Superfamily, Member 7
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Tumor Necrosis Factor-alpha / physiology
Substances
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Antigens, T-Independent
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B-Cell Activating Factor
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Membrane Proteins
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Receptors, Antigen, B-Cell
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TNFSF13B protein, human
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Tnfsf13b protein, mouse
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Tumor Necrosis Factor Receptor Superfamily, Member 7
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Tumor Necrosis Factor-alpha