Abstract
The effects of the 5-HT(3) receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice were examined. The non-competitive NMDA receptor antagonists ketamine (1. 0-10 mg/kg, i.p.) and dizocilpine (0.1 and 0.2 mg/kg, i.p.) each produced a place preference in a dose-dependent manner. The ketamine (10 mg/kg)- and dizocilpine (0.2 mg/kg)-induced place preferences were dose-dependently blocked by pretreatment with ondansetron (0. 03-0.1 mg/kg, s.c.). These results suggest that 5-HT(3) receptor may be involved in the development of the place preferences produced by ketamine and dizocilpine.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Conditioning, Operant / drug effects*
-
Dizocilpine Maleate / pharmacology*
-
Dose-Response Relationship, Drug
-
Excitatory Amino Acid Antagonists / pharmacology*
-
Ketamine / pharmacology*
-
Male
-
Mice
-
Ondansetron / pharmacology*
-
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
-
Receptors, Serotonin / drug effects
-
Receptors, Serotonin / physiology
-
Receptors, Serotonin, 5-HT3
-
Serotonin Antagonists / pharmacology*
Substances
-
Excitatory Amino Acid Antagonists
-
Receptors, N-Methyl-D-Aspartate
-
Receptors, Serotonin
-
Receptors, Serotonin, 5-HT3
-
Serotonin Antagonists
-
Ondansetron
-
Ketamine
-
Dizocilpine Maleate