Abstract
Cortical processing of sensory information begins with the transformation of thalamically relayed signals. We optogenetically silenced intracortical circuits to isolate thalamic inputs to layer 4 neurons and found that intracortical excitation linearly amplified thalamocortical responses underlying frequency and direction selectivity, with spectral range and tuning preserved, and prolonged the response duration. This signal pre-amplification and prolongation enhanced the salience of thalamocortically relayed information and ensured its robust, faithful and more persistent representation.
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Acknowledgements
This work was supported by grants from the US National Institutes of Health (DC008983 to L.I.Z., EY019049 to H.W.T.) and the David and Lucile Packard Foundation (L.I.Z.).
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L.I.Z. conceived and supervised the study. L.L., Y.L. and M.Z. performed the experiments. L.L., H.W.T. and L.I.Z. performed data analysis. H.W.T. and L.I.Z. wrote the paper.
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Li, Ly., Li, Yt., Zhou, M. et al. Intracortical multiplication of thalamocortical signals in mouse auditory cortex. Nat Neurosci 16, 1179–1181 (2013). https://doi.org/10.1038/nn.3493
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DOI: https://doi.org/10.1038/nn.3493
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