Abstract
miR-132 is a CREB-induced microRNA that is involved in dendritic spine plasticity. We found that visual experience regulated histone post-translational modifications at a CRE locus that is important for miR-212 and miR-132 cluster transcription, and regulated miR-132 expression in the visual cortex of juvenile mice. Monocular deprivation reduced miR-132 expression in the cortex contralateral to the deprived eye. Counteracting this miR-132 reduction with an infusion of chemically modified miR-132 mimic oligonucleotides completely blocked ocular dominance plasticity.
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Acknowledgements
We thank L. Dolfi and F. Cremisi for help with ISH. This work was supported by European Union 7th Framework Program (FP2007–2013) grant agreements 223326 and 223524, EXTRAPLAST IIT project, Telethon project GGP09196 and MIUR EpiGen.
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P.T. performed all of the experiments and wrote the manuscript. E.P. performed electrophysiology, ChIP and western blots. A.C. performed ChIP. T.P. wrote the manuscript and supervised the project.
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Tognini, P., Putignano, E., Coatti, A. et al. Experience-dependent expression of miR-132 regulates ocular dominance plasticity. Nat Neurosci 14, 1237–1239 (2011). https://doi.org/10.1038/nn.2920
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DOI: https://doi.org/10.1038/nn.2920
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