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Attractor dynamics of network UP states in the neocortex

Nature volume 423, pages 283–288 (2003)Cite this article

Abstract

The cerebral cortex receives input from lower brain regions, and its function is traditionally considered to be processing that input through successive stages to reach an appropriate output1,2. However, the cortical circuit contains many interconnections, including those feeding back from higher centres3,4,5,6, and is continuously active even in the absence of sensory inputs7,8,9. Such spontaneous firing has a structure that reflects the coordinated activity of specific groups of neurons10,11,12. Moreover, the membrane potential of cortical neurons fluctuates spontaneously between a resting (DOWN) and a depolarized (UP) state11,13,14,15,16, which may also be coordinated. The elevated firing rate in the UP state follows sensory stimulation16 and provides a substrate for persistent activity, a network state that might mediate working memory17,18,19,20,21. Using two-photon calcium imaging, we reconstructed the dynamics of spontaneous activity of up to 1,400 neurons in slices of mouse visual cortex. Here we report the occurrence of synchronized UP state transitions (‘cortical flashes’) that occur in spatially organized ensembles involving small numbers of neurons. Because of their stereotyped spatiotemporal dynamics, we conclude that network UP states are circuit attractors—emergent features of feedback neural networks22 that could implement memory states or solutions to computational problems.

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Figure 1: Two-photon calcium imaging of persistent activity in large neuronal populations.
Figure 2: Spatial structure of synchronous neuronal ensembles.
Figure 3: Spatiotemporal dynamics of synchronous activity.
Figure 4: Synchronous activity is mediated by network UP states.

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Acknowledgements

We thank D. McCormick for advice as well as J. Hopfield and members of our laboratory for comments. Supported by NEI, NINDS, FRM, the Human Frontier Science Program, the New York STAR Center for High Resolution Imaging of Functional Neural Circuits and the John Merck Fund.

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  1. Department of Biological Sciences, Columbia University, New York, New York, 10027, USA

    Rosa Cossart, Dmitriy Aronov & Rafael Yuste

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  1. Rosa Cossart
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  3. Rafael Yuste
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Correspondence to Rosa Cossart.

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Cossart, R., Aronov, D. & Yuste, R. Attractor dynamics of network UP states in the neocortex. Nature 423, 283–288 (2003). https://doi.org/10.1038/nature01614

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