Cocaine abuse results in increased craving for the drug. But in the long run, cocaine intake induces the expression of a microRNA in the brain, and this seems to limit further drug intake.
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Picciotto, M. MicroRNA knocks down cocaine. Nature 466, 194–195 (2010). https://doi.org/10.1038/466194a
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DOI: https://doi.org/10.1038/466194a