Abstract
SPECIFIC families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factor Brn-3.0, and two highly related factors Brn-3.1 and Brn-3.2, are differentially expressed in the developing and mature mamma-lian nervous system1–11. The expression pattern of Brn-3.0 sug-gested that it has an important role in the development of sensory ganglia, as well as red nucleus, inferior olive, and nucleus ambiguus. Analysis of mice null for the Brn-3.0 locus shows that Brn-3.0 is required for the survival of subpopulations of proprioceptive, mechanoreceptive and nociceptive sensory neu-rons, where deletion of the gene affects neurotrophin and neuro-trophin-receptor gene expression. Deletion of Brn-3.0 also alters either differentiation, migration or survival of specific central neuronal populations.
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McEvilly, R., Erkman, L., Luo, L. et al. Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons. Nature 384, 574–577 (1996). https://doi.org/10.1038/384574a0
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DOI: https://doi.org/10.1038/384574a0
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