Abstract
POSITRON emission tomographic (PET) studies of human attention have begun to dissect isolable components of this complex higher brain function, including a midline attentional system in a region of the anterior cingulate cortex1–3. The right hemisphere may play a special part in human attention4; neglect, an important phenomenon associated with damage to attentional systems, is more severe, extensive and long-lasting after lesions to the right hemisphere. Here we use PET measurements of brain blood flow in healthy subjects to identify changes in regional brain activity during simple visual and somatosensory tasks of sustained attention or vigilance. We find localized increases in blood flow in the prefrontal and superior parietal cortex primarily in the right hemisphere, regardless of the modality or laterality of sensory input. The anterior cingulate was not activated during either task. These data localize the vigilance aspects of normal human attention to sensory stimuli, thereby clarifying the biology underlying asymmetries of attention to such stimuli that have been reported in clinical lesions.
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References
Posner, M. I., Petersen, S. E., Fox, P. T. & Raichle, M. E. Science 240, 1627–1631 (1988).
Pardo, J. V., Pardo, P. J., Janer, K. W. & Raichle, M. E. Proc. natn. Acad. Sci. U.S.A. 87, 256–259 (1990).
Corbetta, M., Miezin, F. M., Dobmeyer, S., Shulman, G. L. & Petersen, S. E. Science 248, 1556–1559 (1990).
Heilman, K. M., Watson, R. T., Valenstein, E. & Goldberg, M. E. in Handbook of Physiology: Higher Cortical Functions of the Brain (eds Plum, F. & Mountcastle, V. B.) 5, 461–481 (Am. Physiol. Soc., Washington DC, 1987).
Herscovitch, P., Markham, J. & Raichle, M. E. J. nucl. Med. 24, 782–789 (1983).
Raichle, M. E. et al. J. nucl. Med. 24, 790–798 (1983).
Yamamoto, M., Ficke, D. C. & Ter-Pogossian, M. M. IEEE Trans. nucl. Sci. 29, 529–533 (1982).
Fox, P. T., Mintun, M. A., Reiman, E. M. & Raichle, M. E. J. cereb. Blood Flow Metab. 8, 642–653 (1988).
Fox, P. T., Burton, H. & Raichle, M. E. J. Neurosurg. 67, 34–43 (1987).
Fox, P. T. et al. J. Neurosci. 7, 913–922 (1987).
Talairach J. & Szikla, G. et al. Atlas d'Anatomie Stéréotaxique du Télencéphale (Mason, Paris, 1967).
Goldman-Rakic, P. S. in Handbook of Physiology: Higher Cortical Function of the Brain (eds Plum, F. & Mountcastle, V. B.) 5, 373–417 (Am. Physiol. Soc., Washington DC, 1987).
Fuster, J. M. The Prefrontal Cortex (Raven, New York, 1989).
Cavada, C., Goldman-Rakic, P. S. J. comp. Neurol. 287, 393–421 (1989).
Fox, P. T. & Mintun, M. A. J. nucl. Med. 30, 141–149 (1989).
Mintun, M. A., Fox, P. T. & Raichle, M. E. J. cereb. Blood Flow Metab. 9, 96–103 (1989).
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Pardo, J., Fox, P. & Raichle, M. Localization of a human system for sustained attention by positron emission tomography. Nature 349, 61–64 (1991). https://doi.org/10.1038/349061a0
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DOI: https://doi.org/10.1038/349061a0
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