Abstract
At least four probable components of potassium channels are encoded at the Drosophila Shaker locus, by a family of alternatively spliced transcripts. Alternative splicing may provide one mechanism of generating the remarkable diversity of potassium channels.
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References
Hodgkin, A. L. & Huxley, A. F. J. Physiol., Lond. 117, 500–544 (1952).
Byerly, L. & Masuda, M. O. J. Physiol., Lond. 288, 263–284 (1979).
Meech, R. W. & Standen, N. B. J. Physiol., Lond. 249, 211–239 (1975).
Adams, P. R., Brown, D. A. & Constanti, A. J. Physiol., Lond. 330, 537–572 (1982).
Grega, D. S., Werz, M. A. & MacDonald, R. L. Science 235, 345–348 (1987).
Dunlap, K., Holz, G. G. & Rane, S. G. Trends Neurosci. 10, 241–244 (1987).
Piomelli, D. et al. Nature 328, 38–43 (1987).
Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, 1984).
Belardetti, F., Schacher, S. & Siegelbaum, S. A. J. Physiol., Lond. 374, 289–313 (1986).
Grissmer, S. J. Physiol., Lond. 381, 119–134 (1986).
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Science 237, 749–753 (1987).
Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N. & Jan, L. Y. Science 237, 770–775 (1987).
Kamb, A., Iverson, L. E. & Tanouye, M. A. Cell 50, 405–413 (1987).
Baumann, A. et al. EMBO J. 6, 3419–3429 (1987).
Hagiwara, S. & Siato, N. J. Physiol., Lond. 148, 161–179 (1959).
Connor, J. A. & Stevens, C. F. J. Physiol., Lond. 213, 21–30 (1971).
Ito, I. & Maeno, T. J. Physiol., Lond. 373, 115–127 (1986).
Cassell, J. F., Clark, A. L. & McLachlan, E. M. J. Physiol., Lond. 372, 457–483 (1986).
Kawa, K. J. Physiol., Lond. 385, 189–205 (1987).
Connor, J. A. Fedn Proc. 37, 2139–2145 (1978).
Salkoff, L. Cold Spring Harb. Symp. quant. Biol. 48, 221–232 (1984).
Connor, J. A. & Stevens, C. F. J. Physiol., Lond. 213, 31–53 (1971).
Tanouye, M. A., Ferrus, A. & Fujita, S. C. Proc. natn. Acad. Sci. U.S.A. 78, 6548–6552 (1981).
Jan, Y. N., Jan, L. Y. & Dennis, M. J. Proc. R. Soc. B198, 87–108 (1977).
Alkon, D. L., Lederhendler, I. & Shoukimas, J. L. Science 215, 693–695 (1982).
Timpe, L. C. & Jan, L. Y. J. Neurosci. 7, 1307–1317 (1987).
Wu, C. F. & Haugland, F. J. Neurosci. 10, 2626–2640 (1985).
Noda, M. et al. Nature 312, 121–127 (1984).
Tanabe, T. et al. Nature 328, 313–318 (1987).
Timpe, L. C. et al. Nature 331, 143–145 (1988).
Mount, S. M. Nucleic Acids Res. 10, 459–472 (1982).
Grenningloh, G. et al. Nature 328, 215–220 (1987).
Greenblatt, R. E., Blatt, Y. & Montal, M. FEBS Lett. 193, 125–134 (1985).
Guy, H. R. & Seetharamulu, P. Proc. natn. Acad. Sci. U.S.A. 83, 508–512 (1986).
Noda, M. et al. Nature 320, 188–192 (1986).
Catterall, W. A. A. Rev. Biochem. 55, 953–985 (1986).
Krebs, E. G. & Beavo, J. A. A. Rev. Biochem. 48, 923–958 (1979).
Wharton, K. A., Yedvobnick, B., Finnerty, V. G. & Artavanis-Tsakonas, S. Cell 40, 55–62 (1985).
Leff, S. E., Rosenfeld, M. G. & Evans, R. M. A. Rev. Biochem. 55, 1091–1117 (1986).
Jorgensen, E. M. & Garber, R. L. Genes Dev. 1, 544–555 (1987).
Noda, M. et al. Nature 302, 528–532 (1983).
Solc, C. K., Zagotta, W. N. & Aldrich, R. W. Science 236, 1094–1098 (1987).
Ganetzky, B. & Wu, C. F. A. Rev. Genet. 20, 13–44 (1986).
Itoh, N., Salvaterra, P. & Itakura, K. Drosoph. Inf. Serv. 61, 89 (1985).
Sanger, F. et al. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).
Chen, E. Y. & Seeburg, P. H. DNA 4, 165–170 (1985).
Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55–63 (1987).
Banerjee, U., Renfranz, P. J., Pollock, J. A. & Benzer, S. Cell 49, 281–291 (1987).
Church, G. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 81, 1991–1995 (1984).
Sobel, E. & Martinez, H. M. Nucleic Acids Res. 14, 363–374 (1985).
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Schwarz, T., Tempel, B., Papazian, D. et al. Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature 331, 137–142 (1988). https://doi.org/10.1038/331137a0
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DOI: https://doi.org/10.1038/331137a0
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