EditorialOrganizing action of prenatally administered testosterone propionate on the Tissues mediating mating behavior in the female guinea pig
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Sex differences matter: Males and females are equal but not the same
2023, Physiology and BehaviorEffects of ovariectomy on the inputs from the medial nucleus of the amygdala to the ventromedial nucleus of the hypothalamus in young adult rats
2021, Neuroscience LettersCitation Excerpt :At this phase, the absence of testosterone and the existence of low levels of oestradiol prevent brain masculinization [2–4], at puberty, in the second window of development of the female CNS, the levels of oestradiol increase, promoting neural refinement, namely, increasing the number of cells in the anteroventral periventricular nucleus (AvPv) with the opposite effect in the medial nucleus of the amygdala (MeA) of female rats [5]. The increase in oestradiol will also promote the combination of internal and external information to promote the appropriate adult expression of behaviours, such as reproduction and aggression [4,6–8]. Female sexual behaviour is under the control of a neural circuit that is directly influenced by environmental factors and the ovarian hormones oestradiol and progesterone [9–11].
Can maternal exposure to paracetamol impair reproductive parameters of male rat offspring?
2020, Reproductive ToxicologyCitation Excerpt :These peaks in the perinatal period are called the organizational period. The testosterone produced by the testes of rats reaches the Central Nervous System (CNS), where it is aromatized intro estradiol in the preoptic area (POA) of the hypothalamus [38]. Estradiol, in the intrauterine period, is responsible for the processes of masculinization and defeminization of the hypothalamus.
Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review
2020, British Journal of AnaesthesiaOpposite-sex and same-sex twin studies of physiological, cognitive and behavioral traits
2020, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Human studies of prenatal hormone effects were initially motivated by experimental studies in non-human animals. The pioneering study by Phoenix et al. found that female guinea pigs that were exposed to testosterone prenatally showed masculinized behavior in adulthood (Phoenix, 2009). Since then, numerous studies in non-human mammals have demonstrated effects of testosterone on neurobehavioral sexual differentiation (Constantinescu and Hines, 2012).
The Role of Puberty and Ovarian Hormones in the Genetic Diathesis of Eating Disorders in Females
2019, Child and Adolescent Psychiatric Clinics of North AmericaCitation Excerpt :Taken together, data from adolescence and adulthood provide relatively strong convergent evidence that lower levels of estradiol may be associated with increased genetic effects on binge eating and emotional eating across development. Mechanisms underlying these effects remain unknown, but estrogen is known to be protective against food intake and binge eating in adulthood in animals48–51 and humans.52–54 It may be that lower levels of estradiol during puberty disrupt normative pubertal processes and brain development and increase genetic effects and later phenotypic risk for binge eating in girls.43