Elsevier

Genomics

Volume 87, Issue 6, June 2006, Pages 711-723
Genomics

Promoter motifs of olfactory receptor genes expressed in distinct topographic patterns

https://doi.org/10.1016/j.ygeno.2006.02.005Get rights and content
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Abstract

Novel olfactory receptor-encoding genes that are expressed in olfactory sensory neurons arranged in a clustered pattern in the nasal epithelium, typical of the mOR262 (approved gene symbol Olfr) family, were identified. The genes share sequence motifs upstream of their transcription start sites that are highly related to those previously identified as characteristic of the mOR262 genes, suggesting that these regulatory elements may contribute to governing their unique expression pattern. Promoter analyses of genes encoding class I receptors that are expressed in the dorsal region of the epithelium revealed a different, but again common set of sequence motifs. A prominent feature of the class I gene promoters are multiple O/E-like binding sites, and O/E-type transcription factors that bind to the putative promoter region of class I OR genes were in fact identified. The findings support the concept that common elements in the promoter region of these OR genes may determine their congenic expression pattern in the epithelium.

Keywords

Olfactory system
Topography
Olfactory receptor
Promoter
Gene regulation

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