Neural differentiation of fragile X human embryonic stem cells reveals abnormal patterns of development despite successful neurogenesis
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Highlights
► FX-hESC can differentiate in-vitro into bona-fide neurons. ► Neurogenesis of FX-hESCs recapitulates the in-vivo process of FMR1 downregulation. ► Aberrant development was found already at the early stages of neurogenesis. ► FX neurons express action potentials, but lack synaptic activity.
Keywords
Neural differentiation
Fragile X syndrome
Human embryonic stem cells
Abnormal development
Intellectual disability
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