Trends in Cognitive Sciences
ReviewSpecial Issue: Cognition in Neuropsychiatric DisordersCognition in schizophrenia: core psychological and neural mechanisms
Section snippets
Centrality of cognition in schizophrenia
When we think of the core symptoms of illness, such as schizophrenia, we think of people who hear voices, see visions and have false beliefs about reality (i.e., delusions). However, clinicians have long recognized that abnormalities in cognitive function are a key component of schizophrenia, one of the most debilitating psychiatric disorders. As such, the last three decades have witnessed a relative explosion of research on cognition in schizophrenia, much of it couched within the framework of
Context, proactive control and goal representation in schizophrenia
In previous work based in part upon computational modeling, Cohen and colleagues put forth the hypothesis that intact function of dopamine in DLPFC was responsible for the processing of context, and that a disturbance in this mechanism was responsible for a range of cognitive deficits in schizophrenia (e.g., 7, 8, 9). In this framework context refers to prior task-relevant information, including task instructions, the results of processing prior stimuli, and goals that are represented and
Working memory in schizophrenia
Although there is an enormous amount of work on executive function and proactive cognitive control in schizophrenia, there are perhaps even more data on working memory deficits in this illness 3, 33. However, simply saying that individuals with schizophrenia have deficits on working memory tasks is not particularly informative, as working memory is a complex construct with different subprocesses. To understand what specific aspects of working memory might be impaired in schizophrenia and how
Episodic memory in schizophrenia
When one discusses episodic memory functions a typical focus is on encoding, binding, relational and retrieval mechanisms that are frequently associated with the function of medial temporal regions, including the hippocampus 56, 57. In schizophrenia, there is meta-analytic evidence for greater impairments in relational than item memory [58]. More recently, clinical researchers have begun to use tasks derived from the animal literature on hippocampal function, such as the transitive interference
Concluding remarks
As this brief review highlights, individuals with schizophrenia show significant deficits in a number of different cognitive domains, including executive function, working memory and episodic memory. We have suggested that there is a common mechanism contributing to these deficits – an impairment in proactive control that can influence performance in a wide variety of cognitive domains. Moreover, we have suggested that at the neural level, a common denominator to such deficits may be impaired
Acknowledgements
Deanna Barch receives funding from the NIH, the McDonnell Center for Higher Brain Function, and NARSAD. Alan Ceaser has been funded by the National Science Foundation.
Glossary
- Context
- information that can be used to modify the interpretation of an event or the response of an individual to stimuli in their environment. Context is information that must be ‘actively’ held in mind so that it can be used to mediate task appropriate behavior. Context information can be a specific prior stimulus, the result of processing a sequence of prior stimuli, or more abstract information, such as task instructions. Language processing provides a useful example of context information,
References (100)
Cognition and control in schizophrenia: a computational model of dopamine and prefrontal function
Biol. Psychiatry
(1999)Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients
Biol. Psychiatry
(2006)Prefrontal functioning during context processing in schizophrenia and major depression: an event-related fMRI study
Schizophr. Res.
(2005)Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis
Neurosci. Biobehav. Rev.
(2007)General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance
Biol. Psychiatry
(2011)Variable global dysconnectivity and individual differences in schizophrenia
Biol. Psychiatry
(2011)Brain network connectivity in individuals with schizophrenia and their siblings
Biol. Psychiatry
(2011)- et al.
Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
Schizophr. Res.
(2005) The episodic buffer: A new component of working memory?
Trends Cogn. Sci.
(2000)Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory
Schizophr. Res.
(2004)
Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of Schizophrenia
Schizophr. Res.
Intact and impaired cognitive-control processes in schizophrenia
Schizophr. Res.
Impaired updating of working memory in schizophrenia
Int. J. Psychophysiol.
Working memory in schizophrenia: a systematic study of specific modalities and processes
Psychiatry Res.
Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence
Biol. Psychiatry
Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia
Biol. Psychiatry
Disturbed functional connectivity within brain networks subserving domain-specific subcomponents of working memory in schizophrenia: relation to performance and clinical symptoms
J. Psychiatry Res.
Working memory related gamma oscillations in schizophrenia patients
Int. J. Psychophysiol.
Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
Schizophr. Res.
Inefficient executive cognitive control in schizophrenia is preceded by altered functional activation during information encoding: an fMRI study
Neuropsychologia
A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia
Biol. Psychiatry
Is associative recognition more impaired than item recognition memory in schizophrenia? A meta-analysis
Brain Cogn.
Transitive inference in schizophrenia: Impairments in relational memory organization
Schizophr. Res.
The eyes have it: hippocampal activity predicts expression of memory in eye movements
Neuron
Use of eye movement monitoring to examine item and relational memory in schizophrenia
Biol. Psychiatry
Eye-movement behavior reveals relational memory impairment in schizophrenia
Biol. Psychiatry
Remember and know judgments during recognition in chronic schizophrenia
Schizophr. Res.
Conscious recollection in autobiographical memory: An investigation in schizophrenia
Conscious. Cogn.
Episodic memory in schizophrenia: the influence of strategy use on behavior and brain activation
Psychiatry Res.
Neurocognitive impairment in middle-aged and older adults with bipolar disorder: comparison to schizophrenia and normal comparison subjects
J. Affect. Disord.
Cognitive functioning in patients with schizophrenia and bipolar disorder: a quantitative review
Schizophr. Res.
Spatial working memory performance in patients with schizoaffective psychosis versus schizophrenia: a tale of two disorders?
Schizophr. Res.
Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology
Schizophr. Res.
Are schizophrenia and schizoaffective disorder neuropsychologically distinguishable?
Schizophr. Res.
Impaired top-down control of visual search in schizophrenia
Schizophr. Res.
Failure of schizophrenia patients to overcome salient distractors during working memory encoding
Biol. Psychiatry
Impaired working memory for location but not for colour or shape in visual neglect: a comparison of parietal and non-parietal lesions
Cortex
Working memory: the importance of theta and gamma oscillations
Curr. Biol.
The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study
Biol. Psychiatry
Developing treatments for impaired cognition in schizophrenia
Trends Cogn. Sci.
Neurocognitive predictors of work outcome in recent-onset schizophrenia
Schizophr. Bull.
Neurocognition in first-episode schizophrenia: a meta-analytic review
Neuropsychology
Working memory in schizophrenia: a meta-analysis
Psychol. Med.
CNTRICS final task selection: executive control
Schizophr. Bull.
Improving prefrontal cortex function in schizophrenia through focused training of cognitive control
Front. Hum. Neurosci.
Cognitive control deficits in schizophrenia: mechanisms and meaning
Neuropsychopharmacology
Selective deficits in prefrontal cortex regions in medication naive schizophrenia patients
Arch. Gen. Psychiatry
Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks
J. Abnorm. Psych.
Cognitive control in schizophrenia: psychological and neural mechanisms
Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes
Schizophr. Bull.
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