Cell Stem Cell
Volume 11, Issue 2, 3 August 2012, Pages 220-230
ArticleVCAM1 Is Essential to Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensor to Regulate SVZ Lineage Progression
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Graphical Abstract
Highlights
► Neural stem cells (NSCs) are anchored in the ependymal niche by VCAM1 on their endfeet ► Blocking VCAM1 activates quiescent NSCs to undergo proliferation and neurogenesis ► VCAM1 activates NOX2 to generate the level of ROS needed for NSC maintenance ► VCAM1 acts as an environmental NSC sensor, responding to humoral factors like IL-1β
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These authors contributed equally to this work
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