The projection and synaptic organisation of NTS afferent connections with presympathetic neurons, GABA and nNOS neurons in the paraventricular nucleus of the hypothalamus
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Highlights
► Ascending NTS fibres target PVN-associated neurons. ► Suggest glutamate as the neurotransmitter. ► Anatomical basis for the different functions of cardiovascular receptors.
Abbreviations
BDA
biotin dextran amine
CTB
cholera B toxin subunit
DAB
diaminobenzidine
FG
fluorogold
GABA
gamma aminobutyric acid
HF
heart failure
HRP
horseradish peroxidase
IP
intraperitoneal
MI
myocardial infarction
NGS
normal goat serum
NHS
normal horse serum
NO
nitric oxide
nNOS
neuronal nitric oxide synthase
NTS
nucleus tractus solitarius
PB
phosphate buffer
PFA
paraformaldehyde
PVN
paraventricular nucleus of the hypothalamus
RVLM
rostral ventrolateral medulla
SPN
sympathetic preganglionic neurons
TBS
Tris buffered saline
vGLUT2
vesicular glutamate transporter 2
Key words
nucleus tractus solitarius
paraventricular nucleus of the hypothalamus
nitric oxide
gamma amino butyric acid
spinally projecting presympathetic neurons
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Copyright © 2012 IBRO. Published by Elsevier Ltd.