ReviewInteractions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat
Section snippets
Functional and anatomical differences between the dorsal and ventral mPFC of rats
The mPFC of rats consists of four main divisions which from dorsal to ventral are the medial agranular (AGm) (or medial precentral), the AC (dorsal and ventral divisions), the PL and the IL (Berendse and Groenewegen 1991, Ray and Price 1992, Price 1995, Swanson 1998, Öngür and Price 2000, Heidbreder and Groenewegen 2003). The various subdivisions of the mPFC appear to serve separate and distinct functions. For instance, dorsal regions of mPFC (AGm and AC) have been linked to various motor
Conclusions
In summary, the IL projects to autonomic/visceral-related sites, supporting its role in visceromotor activity, whereas PL/ventral AC primarily projects to limbic-related sites that reportedly affect cognition (Vertes 2004, Gabbott et al 2005). It is obviously the case, however, that complex goal-directed behaviors entail an integration of visceral and cognitive elements. It seems likely that this integration may largely occur at the level of mPFC involving interactions between IL and PL. In the
Acknowledgments
Grant sponsor; NIMH; grant numbers: MH63519 and MH01476.
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