Neuron
Volume 71, Issue 6, 22 September 2011, Pages 1116-1126
ArticleVesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse
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Highlights
► A zinc chelator, ZX1, inhibits presynaptic mf-LTP in WT mice ► Postsynaptic mf-LTP is evident in ZnT3−/− mice lacking synaptic vesicular zinc ► Dialysis of CA3 pyramid with BAPTA inhibits mf-LTP in ZnT3−/− but not WT mice ► A zinc chelator, ZX1, unmasks postsynaptic mf-LTP in rim1α mutant mice
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These authors contributed equally to this work
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Present address: Department of Chemistry, 18-498, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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Present address: Department of Neurobiology, Campus Box 3676, Duke University Medical Center, Durham, NC 27710, USA
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