Post-training cerebellar cortical activity plays an important role for consolidation of memory of cerebellum-dependent motor learning
Highlights
► We examined how the cerebellar cortex acts to consolidate motor memory in mice. ► Adaptation of reflex eye movement was induced by 1 h of training daily for 4 days. ► Daily post-training inactivation of cerebellar cortex abolished adaptation. ► The post-training cortical activity is important for consolidation of motor memory.
Section snippets
Acknowledgements
This study is supported by the research funds of RIKEN and SORST of the Japan Science and Technology Cooperation, and a Grant-in-Aid from the Japan Society for Promotion of Science.
References (29)
- et al.
Effects of reversible pharmacological shutdown of cerebellar flocculus on the memory of long-term horizontal vestibulo-ocular reflex adaptation in monkeys
Neurosci. Res.
(2010) - et al.
Cerebellar function in consolidation of motor memory
Neuron
(2002) - et al.
Adaptation of optokinetic and vestibulo-ocular reflexes to modified visual inputs in the rabbit
Prog. Brain Res.
(1979) A protein synthesis-dependent late phase of cerebellar long-term depression
Neuron
(1996)A non-invasive method for eye position recording with an infra-red TV-camera
Neurosci. Res.
(1990)- et al.
Loss of adaptability of horizontal optokinetic response eye movements in mGluR1 mutant mice
Neurosci. Res.
(2002) - et al.
Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation
Neuroscience
(2006) - et al.
Temporal properties of cerebellar-dependent memory consolidation
J. Neurosci.
(2004) - et al.
Dual involvement of G-substrate in motor learning revealed by gene deletion
Proc. Natl. Acad. Sci. U.S.A.
(2009) - et al.
Long-lasting forms of synaptic potentiation in the mammalian hippocampus
Learn. Mem.
(1996)
The Cerebellum and Neural Control
(1984)
Long-term depression
Annu. Rev. Neurosci.
(1989)
Cerebellar long-term depression: characterization, signal transduction, and functional roles
Physiol. Rev.
(2001)
Destruction of inferior olive induces rapid depression in synaptic action of cerebellar Purkinje cells
Nature
(1979)
Cited by (0)
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.