Recombinant human erythropoietin prevents motor neuron apoptosis in a rat model of cervical sub-acute spinal cord compression
Section snippets
Acknowledgements
The authors wish to thank Dr. Han Kun for his expertise and technical assistance, Prof. Xiuli Ju and Dr. Yingqian Zhang for their kind review of the manuscript, and Dr. Li Ming and Dr. Xia Qigan for their outstanding animal husbandry. This work was supported by grant from the National Natural Science Foundation of China (No. 30271318 M.H.).
References (13)
- et al.
Repair of chronic spinal cord injury
Exp. Neurol.
(2003) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
A sensitive and reliable locomotor rating scale for open field testing in rats
J. Neurotrauma
(1995) - et al.
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Proc. Natl. Acad. Sci. U.S.A.
(2000) - et al.
Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
Proc. Natl. Acad. Sci. U.S.A.
(2002) - et al.
Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
Proc. Natl. Acad. Sci. U.S.A.
(2002)
Cited by (29)
Short erythropoietin-derived peptide enhances memory, improves long-term potentiation, and counteracts amyloid beta–induced pathology
2019, Neurobiology of AgingCitation Excerpt :The canonical signaling of EPO is involved in regulating neuronal plasticity, neuroprotective, anti-apoptotic, and anti-inflammatory activities (Maiese et al., 2012; Sargin et al., 2010; Siren et al., 2009; Yu et al., 2002). Notably, systemically injected EPO improves neurological functions and reduces brain damage after traumatic brain and spinal cord injuries (Brines et al., 2000; Celik et al., 2002; Gantner et al., 2017; Li et al., 2016b; Ning et al., 2011), cerebral ischemia (Sakanaka et al., 1998; Siren et al., 2001), experimental autoimmune encephalomyelitis (Li et al., 2004), and status epilepticus (SE) (Chu et al., 2008). At the behavioral level, EPO treatment has been shown to improve cognitive functions, in both healthy volunteers (Miskowiak et al., 2008b) and patients with chronic kidney disease (Grimm et al., 1990; Kambova, 1998; Pickett et al., 1999), neuropsychiatric disorders (Ehrenreich et al., 2007; Miskowiak et al., 2014), and type-1 diabetes (Kristensen et al., 2013), instigating further research to elucidate the mechanisms of the cognitive-enhancing effect of EPO.
A sequential delivery system employing the synergism of EPO and NGF promotes sciatic nerve repair
2017, Colloids and Surfaces B: BiointerfacesCitation Excerpt :Accumulating evidence has shown that both the hematopoietic cytokine erythropoietin (EPO) and the nerve growth factor (NGF) have therapeutic effects on the peripheral nerve injuries, such as sciatic nerve, optical nerve and facial nerve injuries [1], yet through different action mechanisms. It was demonstrated that the mechanisms of NGF involve the activation of STAT3 signaling pathway as well as promoted regeneration of both sensory and motor axons after axotomized sciatic nerve injury [2,3]; while the roles of EPO in neuroprotection involve the upregulation of growth associated protein-43 [4], RhoA/ROCK signaling pathway [5], and the inhibition of neuron apoptosis after injury [6]. The different mechanisms of NGF and EPO suggest the potential of enhancing nerve repair through the synergism of the two.
Reduced antioxidant defense and increased oxidative stress in spinal cord injured patients
2012, Archives of Physical Medicine and RehabilitationHyaluronan tetrasaccharide in the cerebrospinal fluid is associated with self-repair of rats after chronic spinal cord compression
2012, NeuroscienceCitation Excerpt :For the current study, we developed a chronic spinal cord compression model. There have been previous experimental animal models of chronic spinal cord compression, including the placement of screws and subsequent gradual tightening of the screws (Ning et al., 2011; Al-Mefty et al., 1993; Harkey et al., 1995), the epidural transplantation of tumor cells in rats (Delattre et al., 1989; Manabe et al., 1989), and the epidural implantation of expanding materials (Cheung et al., 2009; Kasahara et al., 2006; Hu et al., 2011). Many investigators have used the twy mice, which is a model of spinal ligament ossification (Inukai et al., 2009; Yu et al., 2009; Takenouchi et al., 2008; Uchida et al., 2008).
Motor, sensitive, and vegetative recovery in rats with compressive spinal-cord injury after combined treatment with erythropoietin and whole-body vibration
2021, Restorative Neurology and Neuroscience