State-dependent sculpting of olfactory sensory neurons is attributed to sensory enrichment, odor deprivation, and aging
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Acknowledgements
We would like to thank our FSU undergraduate scholars for their assistance with changing of the mice cages, odor stimulation, neuron counting, or routine technical assistance. We also thank Drs. Peter Mombaerts and Leonard Kazcmarek for the donation of the odor receptor-tagged and Kv1.3−/− mice, respectively, and Dr. Stanley Watson for his generous gift of the Ki67 antiserum. This work was supported by grants DC03387 and DC00044 from the National Institute of Deafness and Communication Disorders
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2020, Cell ReportsCitation Excerpt :To do so, we used UNO, a procedure that provides a simple method for reproducibly reducing olfactory stimulation (broadly defined here as both odor- and mechanically derived; Grosmaitre et al., 2007) on the closed side of the OE, as well as a within-animal control (the open side of the OE). Previous studies have found that UNO causes both selective changes in the transcript levels of specific ORs (Cavallin et al., 2010; Coppola and Waggener, 2012; Fischl et al., 2014; Santoro and Dulac, 2012; Zhao et al., 2013) and the abundance of OSNs of corresponding subtypes (Cavallin et al., 2010; Santoro and Dulac, 2012; Zhao et al., 2013) on the closed side of the OE relative to the open side. After defining a set of OSN subtypes with altered representation following UNO, we investigated whether selective changes in neurogenesis contribute to the observed changes in OSN abundance.
3.30 - Regeneration in the Olfactory Bulb
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionChronic perinatal odour exposure with heptaldehyde affects odour sensitivity and olfactory system homeostasis in preweaning mice
2018, Behavioural Brain ResearchAnatomical and molecular consequences of Unilateral Naris Closure on two populations of olfactory sensory neurons expressing defined odorant receptors
2016, Neuroscience LettersCitation Excerpt :In the closed side, a general reduction of the number of OSNs is observed [9]. However, at the level of the individual populations expressing defined ORs, the results are more balanced with increase in the number of neurons of some populations and decrease of others [7,13,38]. Here, by counting the GFP labeled cells in two gene-targeted strains, we confirm that changes induced by UNO are different depending on the population observed: while the M71 population appears unaffected (Fig. 2), the density of MOR23 neurons is reduced in the closed side (Fig. 1).
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Current address: Department of Medicine, University of Texas Health Sciences Center, San Antonio, TX, United States.