Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1α enhances α-synuclein oligomerization and down regulates AKT/GSK3β signaling pathway in human neuronal cells that inducibly express α-synuclein
Section snippets
Acknowledgments
We thank Ms. Katrina Willams and Dr. Brian M. Necela at Mayo Clinic for their assistance in Quantitative Real time PCR analysis, Dr. Daniel P. Kelly at Washington University for providing PGC-1α antibody. This study was funded by Grant No. P50NS40256 from the National Institute of Health and by the Mayo Foundation (S.H. Yen).
References (25)
- et al.
Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease
J. Biol. Chem.
(2002) - et al.
Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
Neurobiol. Dis.
(2006) - et al.
Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues
Biochim. Biophys. Acta
(2009) - et al.
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Cell
(2006) - et al.
Alpha-synuclein and its disease-related mutants interact differentially with microtubule protein tau and associate with the actin cytoskeleton
Neurobiol. Dis.
(2007) - et al.
α-Synuclein promotes mitochondrial deficit and oxidative stress
Am. J. Pathol.
(2000) - et al.
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
Cell
(2006) - et al.
Inhibition of prolyl hydroxylase protects against MPTP-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson's disease
J. Biol. Chem.
(2009) - et al.
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
Cell
(2004) - et al.
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
Cell
(2006)
The cybrid model of sporadic Parkinson's disease
Exp. Neurol.
(2009)
Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response
Aging Cell.
(2008)
Cited by (0)
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.