Distribution and cellular localization of high mobility group box protein 1 (HMGB1) in the spinal cord of a transgenic mouse model of ALS
Section snippets
Acknowledgments
The financial supports of MIUR (project FIRB Negoziali, Protocol RBNEO1B5WW_008) and of the Italian Ministry for Health (RF Malattie Neurodegenerative) are gratefully acknowledged.
References (23)
- et al.
Lessons from models of SOD1-linked familial ALS
Trends Mol. Med.
(2004) - et al.
Neurodegeneration in amyotrophic lateral sclerosis: the role of oxidative stress and altered homeostasis of metals
Brain Res. Bull.
(2003) - et al.
Altered expression of novel genes in the cerebral cortex following experimental brain injury
Mol. Brain Res.
(2002) - et al.
Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis
Biochem. Biophys. Res. Commun.
(2003) - et al.
Persistent activation of p38 mitogen-activated protein kinase in a mouse model of familial amyotrophic lateral sclerosis correlates with disease progression
Mol. Cell Neurosci.
(2003) - et al.
High-mobility group box 1 (HMGB1) protein: friend and foe
Cytokine Growth Factors Rev.
(2006) - et al.
Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS
Mol. Cell Neurosci.
(2006) - et al.
Immune reactivity in a mouse model of familial ALS correlates with disease progression
Neurology
(2001) - et al.
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
J. Exp. Med.
(2000) - et al.
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
Science
(2003)
From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS
Nat. Rev. Neurosci.
(2001)
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Interplay between immunity and amyotrophic lateral sclerosis: Clinical impact
2021, Neuroscience and Biobehavioral ReviewsImplication of HMGB1 signaling pathways in Amyotrophic lateral sclerosis (ALS): From molecular mechanisms to pre-clinical results
2020, Pharmacological ResearchCitation Excerpt :These findings support the pathogenic role of HMGB1 in ALS, suggesting that HMGB1 may be a key player in the pro-inflammatory processes that exacerbate disease progression in ALS. The observed nuclear to cytoplasmic translocation of HMGB1 in the reactive astrocytes and microglia in ALS patients as well as animal models indicates the plausible pathogenic role for HMGB1 in ALS [19,48,49]. It is of no surprise that astrocytes are highly implicated in neurodegeneration and disease progression in ALS [50].
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