Original Report(+)-Naloxone, an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor, Reverses Multiple Models of Chronic Neuropathic Pain in Rats
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Key words
TLR4
neuropathic pain
chronic constriction injury
spinal nerve ligation
HEK293-TLR4
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This work was funded in part by NIH Grants DA024044, DE017782, DA023132 and NIDA contract N01DA-9-8883. This work was also supported in part by the NIH Intramural Research Programs of NIDA and NIAAA. Mark R. Hutchinson is a NHMRC CJ Martin Fellow (ID 465423; 2007-2010) and an Australian Research Council Research Fellow (DP110100297). HEK-TLR4 cells were gifted from Avigen.
Copyright © 2012 American Pain Society. Published by Elsevier Inc. All rights reserved.