Archival ReportDorsomedial Prefrontal Cortex Mediates the Impact of Serotonin Transporter Linked Polymorphic Region Genotype on Anticipatory Threat Reactions
Section snippets
Methods and Materials
Studies were approved by local medical ethical committees from Radboud University Medical Centre and University Medical Centre Utrecht (UMCU), respectively.
Subject Descriptives
For sample 1, genotype distribution was in accordance with previous studies and in Hardy-Weinberg equilibrium (p = .36). As intended, selection led to a higher proportion of homozygotes in sample 2 (Table 1). There were no significant differences in either experiment between the genotype groups with regard to sex distribution, age, and trait anxiety (all p values > .09; Table 1). Given that subjects in sample 1 were all male subjects, sex was controlled for in the genotype analyses reported
Discussion
The identification of neurobiological pathways underlying interindividual differences in psychophysiological reactions during the anticipation of adversity has the exciting outlook of uncovering fundamental mechanisms that might determine vulnerability to anxiety disorders. Here, we validate across two independent samples with different experimental setups that a genetic variation in the 5-HTTLPR predicts psychophysiological reactions to threat mediated by its impact on neural processing in the
Acknowledgments and Disclosures
FK, MK, JLK, GvW, GF, and JMPB designed the experiments. FK and MK performed data analyses. BF, IH, RSO, and FK were responsible for genetic analyses. FK, MK, GF, and JMPB wrote the article. All authors commented on previous versions of the manuscript and agreed upon the final version of the manuscript.
This work was supported by funding from the Dutch organization for scientific research (NWO) through grants awarded to GF (VIDI grant) and GvW (VENI grant). We acknowledge technical assistance
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Cited by (0)
- 1
Authors FK and MK contributed equally to this work.
- 2
Authors GF and JMPB contributed equally to this work.