Priority CommunicationMineralocorticoid Receptor Blockade Prevents Stress-Induced Modulation of Multiple Memory Systems in the Human Brain
Section snippets
Participants and Design
Eighty healthy, right-handed, nonsmoking university students with normal or corrected to normal vision and without any current medical conditions, medication intake, lifetime history of any neurological or psychiatric disorders, or any contraindications for magnetic resonance imaging participated in this experiment (age: mean = 24.6 years, SEM = .3 years). All participants provided written informed consent for participation in the study, which was approved by the ethics committee of the medical
Subjective and Physiological Measures
Changes in subjective feeling, blood pressure, and salivary cortisol verified the successful stress induction. Participants who underwent the SECPT rated the treatment as significantly more stressful, painful, and unpleasant than participants who underwent the control manipulation (all F > 120, all p < .001). Moreover, systolic and diastolic blood pressure increased in response to the SECPT but not in response to the control manipulation (treatment × time point of measurement interactions: both
Discussion
The present findings show for the first time in humans the critical role of the MR in the modulatory effect of stress on the engagement of multiple memory systems. Our results confirm previous studies suggesting a shift from hippocampus-dependent declarative to dorsal striatum-dependent procedural learning after stress 19, 20, 28. Stress (after placebo) reduced declarative task knowledge and increased the use of procedural multi-cue strategies. In addition, dorsal striatal activation correlated
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Stress and the control of remembering: balancing hippocampal and striatal forms of memory retrieval
2023, Current Opinion in Behavioral SciencesAn fMRI meta-analysis of the role of the striatum in everyday-life vs laboratory-developed habits
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2022, NeuronCitation Excerpt :More specifically, it has been demonstrated across tasks and species that stress or corticosteroid administration before learning induces a rapid shift from reflective “cognitive” memory systems, such as the hippocampus or PFC, to more reflexive “habit” systems, such as the amygdala or dorsolateral striatum (Kim et al., 2001; Schwabe et al., 2007; Siller-Pérez et al., 2017; Simon-Kutscher et al., 2019; Vogel et al., 2017; Wirz et al., 2018). Converging lines of evidence from pharmacological and behavioral genetics studies suggest that this initial shift toward “habit” memory under stress is operated by non-genomic corticosteroid action via the MR (Schwabe et al., 2010, 2013; Wirz et al., 2017a), presumably in close interaction with noradrenergic activity (Packard and Goodman, 2012; Wirz et al., 2017b), while the consequent consolidation of striatal memory depends on the GR (Siller-Pérez et al., 2017). Notably, this shift from “cognitive” toward “habit” memory is not only observed during initial memory formation but also at retrieval (Elliott and Packard, 2008; Zerbes et al., 2020; Zerbes and Schwabe, 2021).
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