Archival ReportHigher Serotonin 1A Binding in a Second Major Depression Cohort: Modeling and Reference Region Considerations
Section snippets
Subjects
Thirty subjects who met DSM-IV (17) criteria for a current major depressive episode and 51 control subjects were included. Inclusion criteria were assessed through history, chart review, Structured Clinical Interview for DSM-IV Axis I Disorders (18), review of systems, physical examination, routine blood tests, pregnancy test, urine toxicology, and electrocardiogram. The Beck Depression Inventory (19), Hamilton Depression Rating Scale (20), and Global Assessment Scale (21) assessed subjective
Replication
The previous cohort NRM have higher [11C]WAY-100635 BPF compared with previous control subjects (df = 1,48; F = 4.621; p = .037). The new cohort NRM have higher [11C]WAY-100635 BPF compared with the new control subjects (df = 1,29; F = 4.606; p = .04; Figure 1). Combining the previous and new cohort NRM and control subjects, the NRM have higher BPF than control subjects (df = 1,79; F = 17.77; p = .0001; Figure 2). As mentioned above, groups differed in ID and IM. When IM is added to the model,
Replication
We sought to replicate our findings and to reconcile our data with previous publications. In the previous cohort, new cohort, and the combined cohort of 51 control subjects and 30 NRM MDD subjects, NRM have higher 5-HT1A BPF compared with control subjects (Figure 1). This was the case even though the second cohort included only nine healthy control subjects. Strikingly, the magnitude of difference between control and NRM MDD subjects is nearly identical to that observed in the previous cohort
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2019, Journal of Affective DisordersCitation Excerpt :A limitation of the [11C]DASB ligand is the lack of a valid reference region, since binding sites are present throughout the brain. Methods that require the presence of a valid reference region (such as SRTM), when employed using an invalid reference region instead, underestimate BPND binding potentials (Turkheimer et al., 2012); naturally, therefore, results are less accurate (Oquendo et al., 2007b; Parsey et al., 2005; Parsey et al., 2010; Ito et al., 2001). To overcome this limitation, we have employed the HYDECA method for estimating VND, and thus BPP and BPND, without the need for a reference region.