Archival ReportDrug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal
Section snippets
Animals
Two-month-old male BALB/c mice were obtained from Taconic (Germantown, New York). All animals were housed in groups of four or five and were maintained under standard laboratory conditions (12/12-hour light/dark cycle: lights on at 8:00 pm, 22 ± 2°C, food and water ad libitum). The treatment of the animals was in accordance with the European Community Council directive 86/609/EEC and with the Guide for Care and Use of Laboratory Animals established by the National Institutes of Health of the
Disruption of Hippocampal Neurogenesis Has No Effect on Sensitivity to Stress
To determine whether loss of neurogenesis alters sensitivity to stress, we compared the responses of irradiated and non-irradiated mice to UCMS. In vehicle-treated mice, UCMS induced a gradual deterioration of coat state that reached significance by 4 weeks after beginning the stress (p < .001) and worsened until the end of the stress procedure (p < .001; Figure 2A). This effect was accompanied by reduced grooming in the splash test (p < .01; Figure 2B) and increased latency to eat in the NSF
Discussion
The UCMS-induced behavioral changes were reversed by several compounds endowed with AD-like properties, such as fluoxetine and imipramine, as well as a CRF1 antagonist (SSR125543) and a V1b antagonist (SSR149415). The x-irradiation of the hippocampus had no effect per se in the UCMS procedure, suggesting that a loss of hippocampal neurogenesis does not induce a depressive-like behavior and does not worsen the deteriorations induced by the UCMS. Nevertheless, irradiation completely abolished the
References (55)
- et al.
Chronic stress attenuates glucocorticoid negative feedback: Involvement of the prefrontal cortex and hippocampus
Neuroscience
(2003) - et al.
Neural plasticity to stress and antidepressant treatment
Biol Psychiatry
(1999) - et al.
Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness
Biol Psychiatry
(2003) - et al.
Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039
Biochem Biophys Res Commun
(2004) - et al.
Structural plasticity and tianeptine: Cellular and molecular targets
Eur Psychiatry
(2002) - et al.
Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: The first 20 patients treated
J Psychiatr Res
(2000) - et al.
Treatment of depression with the CRH-1-receptor antagonist R121919: Endocrine changes and side effects
J Psychiatr Res
(2003) - et al.
Chronic mild stress-induced anhedonia: A realistic animal model of depression
Neurosci Biobehav Rev
(1992) - et al.
Correlations between behaviours in the elevated plus-maze and sensitivity to unpredictable subchronic mild stress: Evidence from inbred strains of mice
Behav Brain Res
(2005) - et al.
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol
Eur J Pharmacol
(2005)
Recent advances in animal models of chronic antidepressant effects: The novelty-induced hypophagia test
Neurosci Biobehav Rev
Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression
Pharmacol Biochem Behav
Functional implications of decreases in neurogenesis following chronic mild stress in mice
Neuroscience
Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets
NeuroRx
HPA axis dysfunction in unmedicated major depressive disorder and its normalization by pharmacotherapy correlates with alteration of neural activity in prefrontal cortex and limbic/paralimbic regions
Psychiatry Res
Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment
Biol Psychiatry
Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
Science
Anna-Monika-Prize paperThe hypothalamic-pituitary-adrenal system in depression
Pharmacopsychiatry
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis
J Neurosci
Hippocampal volume reduction in major depression
Am J Psychiatry
Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up
J Clin Psychiatry
Course of illness, hippocampal function, and hippocampal volume in major depression
Proc Natl Acad Sci U S A
Hippocampal atrophy in recurrent major depression
Proc Natl Acad Sci U S A
An update on regional brain volume differences associated with mood disorders
Curr Opin Psychiatry
Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders
Arch Gen Psychiatry
Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
J Neurosci
Cell proliferation in adult hippocampus is decreased by inescapable stress: Reversal by fluoxetine treatment
Neuropsychopharmacology
Cited by (452)
Aerobic exercise improves depressive symptoms in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease
2024, IBRO Neuroscience ReportsAstrocyte-derived lactate in stress disorders
2024, Neurobiology of DiseaseTargeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy
2024, Acta Pharmaceutica Sinica B