Short communicationBehavioural deficits associated with maternal immune activation in the rat model of schizophrenia
Highlights
► The MIA model produces schizophrenia-like memory impairment in rats. ► MIA produces a reduced reinstatement of rearing after a change in context. ► MIA animals show a less persistent reinstatement of rearing after contextual change. ► MIA is associated with schizophrenia-like contextual processing impairments. ► These impairments may be associated with damage to the hippocampus or its afferents.
Section snippets
Acknowledgements
This research was supported by a grant from the Health Research Council of New Zealand. We would also like to thank Saralee Illingworth for her involvement.
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2019, Behavioural Brain ResearchCitation Excerpt :In rats, many studies expose pregnant rats to Poly (I:C) at GD14 (GD15 if the first day of pregnancy is defined as GD1 rather than GD0). This mid-late gestational exposure results in a range of behavioural changes that overlap with both mid and late gestational MIA in mice, and support the model’s face validity for positive, negative and cognitive symptoms of schizophrenia [4–6]. Previous work from our group has attempted to replicate the dissociation of hyperdopaminergic and cognitive behavioural phenotypes observed for mid- and late-gestation MIA in mouse studies, in rats [7].