Research reportInactivation of dorsolateral striatum enhances sensitivity to changes in the action–outcome contingency in instrumental conditioning
Section snippets
Subjects and apparatus
Thirty-two naïve male Long-Evans rats weighing between 450 and 510 g were housed singly, maintained on a 14:10 h light–dark cycle, and handled daily for one week prior to surgery. Training and testing took place in 16 Med Associates (Vermont) operant chambers, each equipped with a pump with a syringe which delivered 0.1 ml of 20% sucrose solution into a recessed magazine, and a house light mounted on the wall opposite of the food magazine. Computers equipped with the MED-PC program controlled the
Placement of the implanted cannulae
Fig. 1 provides a schematic representation of the cannulae placement in the striatum. As shown in this figure, the cannulae were primarily placed in the dorsolateral region of the striatum.
Omission session behavior
The mean response rates on the last day of lever-press training are presented as the baseline in Fig. 2 (first data point in the graphs). Using treatment (muscimol and vehicle) and contingency (omission and yoked) as factors, a two-way ANOVA was conducted. No interaction between treatment and contingency was
Discussion
This study consisted of three phases: (1) lever-press training; (2) omission session after muscimol or vehicle infusion; (3) extinction test without drug infusion. Such a design aimed to assess whether DLS inactivation would affect learning during the omission session, i.e. learning about the complete reversal in instrumental contingency. As we predicted on the basis of previous work, rats given vehicle infusions were insensitive to the imposition of the omission contingency and failed to learn
Acknowledgements
This research was supported by an NSF graduate fellowship to HHY, NSF grant 9985417 to BJK and NIMH grant MH 56446 to BWB.
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