Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio)
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Highlights
► mtDNA replication is inactive in zebrafish embryos but in the exocrine pancreas. ► mtDNA helicase shows different regulation respect to replicative genes. ► mtDNA transcription is already active before mtDNA replication. ► An active OxPhos system is necessary during early zebrafish embryogenesis. ► Danio rerio is a good model for investigation of mitochondrial disease.
Keywords
Danio rerio
Mitochondrial DNA
Respiratory chain complex
Embryo development
Mitochondrial transcription
Mitochondrial replication
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