Elsevier

Genomics

Volume 82, Issue 3, September 2003, Pages 412-415
Genomics

Short communication
Identification of two new members of the CSMD gene family☆

https://doi.org/10.1016/S0888-7543(03)00149-6Get rights and content

Abstract

CSMD1 is a putative suppressor of squamous cell carcinomas mapping to human chromosomal region 8p23. We have cloned two new members of this gene family, CSMD2 and CSMD3. The three CSMD proteins have very similar structures, each consisting of 14 CUB domains separated from one another by a sushi domain, an additional uninterrupted array of sushi domains, a single transmembrane domain, and a short cytoplasmic tail. CUB and sushi domains are thought to be sites of protein–protein or protein–ligand interactions, suggesting that CSMD proteins are either transmembrane receptors or adhesion proteins. The cytoplasmic tail sequences are highly conserved within the vertebrate lineage. CSMD2 maps to a chromosomal region that may contain a suppressor of oligodendrogliomas, yet its expression is elevated in some head and neck cancer cell lines. Functional overlap between the CSMD1 and the CSMD2 proteins may modify the phenotype resulting from the loss of either protein in tumors.

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Acknowledgements

The authors thank Benton Tong, Wen Jiang, Toni Richter, and Paul Goodfellow for their excellent advice and considerable help with the project and the manuscript. The project was supported by NIH Grant R01CA58473 to S.B.S. W.L.L. was supported by a summer research fellowship from the Dean’s office, Washington University School of Medicine.

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    Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AY210418 and AY210419.

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