Chemical organization of projection neurons in the rat accumbens nucleus and olfactory tubercle
Section snippets
Experimental procedures
The procedures of the present experiments were approved by the Animal Care and Use Committee at the Graduate School of Medicine in Kyoto University, Japan. In all the experiments of the present study, adult male Wistar rats (200–250 g body weight; Japan SLC, Shizuoka, Japan) were used. We tried to minimize the number of animals used and their suffering.
Distribution of immunoreactivities for PPD, PPE, PPTA and PPTB in the ventral pallidal and ventral mesencephalic regions
First, the distributions of neuropil immunoreactivities for PPD, PPE, PPTA and PPTB were examined in the regions that were known to receive axonal projection from the Acb and OT. The VP, one of the main targets of ventral striatal projection neurons, was roughly divided into three subregions according to Zahm (1989) and Zahm et al. (1996). In the subcommissural ventral pallidal regions, immunoreactivity for PPTA (Fig. 1c),
- ac
anterior commissure
- AcbC
core region of the Acb
- AcbS
shell region of the
Abbreviations used in the figures
Discussion
In the present study, we examined the chemical characteristics of ventral striatal projection neurons; the results were summarized and compared with those of the dorsal striatal projection neurons in Fig. 11. Although the data of PPTA- and PPTB-immunoreactive projection neurons were omitted from Fig. 11 for simplicity, the results of PPTA-immunoreactive projection neurons were similar to those of PPD-immunoreactive neurons. It was characteristic of the OT that no neurons project to the ventral
Acknowledgements
The authors gratefully acknowledge Mr. Akira Uesugi and Ms Keiko Okamoto for their photographic help. This work was supported by Grants-in-Aid from the Ministry of Education, Science, Sports and Culture of Japan (12308039, 13035026, 13041024, 14017050, 15700274 and 15029224), and a grant from Kyowa-Hakko Co., Ltd.
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