Elsevier

Neuroscience Letters

Volume 232, Issue 3, 5 September 1997, Pages 127-130
Neuroscience Letters

The dynamics of nitric oxide release measured directly and in real time following repeated waves of cortical spreading depression in the anaesthetised cat

https://doi.org/10.1016/S0304-3940(97)00604-6Get rights and content

Abstract

Cortical application of crystalline KCl in male cats anaesthetised with α-chloralose induced four transient negative deflections in cortical direct current (d.c.) potential. In vehicle treated animals d.c. shifts were associated with a hyperaemia and a multiphasic nitric oxide (NO) release. In these animals, the first negative shift in d.c. potential produced a significantly larger NO electrode current, when compared to subsequent cortical depolarisations. However, regional cerebrovascular laser Doppler flux (rCBFLDF) increases were similar for each event. In l-NG-nitro-l-arginine (l-NAME; 10 mg/kg i.v. infused over 30 min) treated animals, d.c. shifts were also associated with NO release following a multiphasic waveform and increase in rCBFLDF, but were significantly attenuated when compared to controls.

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