Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats
Section snippets
Acknowledgements
We are grateful to Mr. Ming-Chieh Ma and Miss Terry Liu for helping the experiment and to Dr. Dar-Shaong Hwang for biostatistics. Supported by Department of Ophthalmology Research Fund, NYEE, Glaucoma Foundation, New York, NY; Leon Lowenstein Foundation, Achelis and Bodman Foundation, and NIH, EY 11295, NSC 89–2320-B002–171.
References (19)
- et al.
Astrocytes in culture express the full-length TrkB receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats
Neurosci. Lett.
(2000) - et al.
Programmed cell death of retinal ganglion cells during experimental glaucoma
Exp. Eye Res.
(1995) - et al.
Light regulates expressions of brain-derived neurotrophic factor mRNA in rat visual cortex
Proc. Natl. Acad. Sci. USA
(1992) - et al.
Brain derived neurotrophic factor/neurotrophin-4 receptor TrkB is localized on ganglion cells and dopaminergic amacrine cells in the vertebral retina
J. Comp. Neurol.
(1997) - et al.
At least two mechanisms are involved in the death of retinal ganglion cells following target ablation in neonatal rats
J. Neurosci.
(1995) - et al.
Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma
Arch. Ophthalmol.
(1996) - et al.
Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice
J. Neurochem.
(2001) - et al.
BDNF down-regulates neurotrophin responsiveness, trkB protein and trkB mRNA levels in cultured rat hippocampal neurons
Eur. J. Neurosci.
(1996) - et al.
Protection of axotomized retinal ganglion cells by adenovirally delivered BDNF in vivo
Eur. J. Neurosci.
(1998)
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2022, Ageing Research ReviewsCitation Excerpt :Additionally, a study by Chen et al. (2010a) showed that increased complement activation in the aged retina contributes to RGC death in mouse eyes. While neurotrophins such as brain-derived neurotrophic factors (BDNF) are produced by both RGCs (Herzog and von Bartheld, 1998) and astrocytes (Moretto et al., 1994) to promote RGC health (Ko et al., 2001; Domenici et al., 2014), age-related decline in BDNF levels impairs RGC function (Erickson et al., 2010; Gupta et al., 2014). Similarly, elevated IOP significantly delays functional recovery of RGCs in older mice eyes (Lee et al., 2022), implicating detrimental effects of increased IOP in older vs. younger individuals.
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2022, Survey of OphthalmologyCitation Excerpt :Prior experimental studies have shown that both topical and intravitreal BDNF were effective in activating RGC pro-survival signaling pathways after ocular hypertensive damage42,114; however, it seems that the effect is dose dependent. While repeated intraocular injections of BDNF at concentration of 1.0µg/µL in rat eyes with moderate ocular hypertension resulted in 2 weeks of lasting increase in RGC survival,114 high-doses BDNF as exposed on cultured rat hippocampal neurons and intravitreally injected in animal models of optic nerve injury, caused a rapid and significant downregulation of tropomyosin receptor kinase expression which reduced BDNF effectiveness.31,54 Recently, GDNF and CNTF have been shown to regulate the survival, development, and function of the nervous system by activating tyrosine kinases.