Elsevier

Appetite

Volume 1, Issue 4, December 1980, Pages 299-315
Appetite

Release of feeding by the sweet taste in rats: Oropharyngeal satiety*

https://doi.org/10.1016/S0195-6663(80)80041-9Get rights and content

In rats which are hungry but not thirsty, the intake of a saccharin solution occurs in discrete “meals”. We show that the control of meal size in this case is exclusively oropharyngeal. The augmentation of postingestive factors has no effect on meal size or on intake pattern. This is true whether they are augmented during the intake period by concurrent injections, or prior to it by gavage. Therefore, oropharyngeal factors such as taste can initiate, and also terminate, a “meal” under these special conditions.

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Cited by (44)

  • Using Postmeal Measures and Manipulations to Investigate Hippocampal Mnemonic Control of Eating Behavior

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    Citation Excerpt :

    In these experiments, animals were given limited exposure to saccharin to reduce the likelihood of any conditioned responses to the taste. Under such conditions, saccharin has minimal postingestive gastric consequences (Mook et al., 1980; Renwick, 1985; Sclafani and Nissenbaum, 1985; Renwick, 1986; Foletto et al., 2016), and unlike sucrose and chow, saccharin meal timing and size are determined primarily by oropharyngeal rather than gastrointestinal processes (Kushner and Mook, 1984; Renwick, 1985; Sclafani and Nissenbaum, 1985; Renwick, 1986). As in the case of chow and sucrose intake, we found that postmeal dHC inactivation accelerates the onset of the next saccharin meal (Hannapel et al., 2019) and doubles the amount of saccharin consumed during the next meal (Briggs et al., 2021b; Hannapel et al., 2019).

  • Memory and eating: A bidirectional relationship implicated in obesity

    2022, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    In these experiments, animals are given limited exposure to saccharin to reduce the likelihood of any conditioned responses to the taste. Under such conditions, saccharin has minimal postingestive consequences (Foletto et al., 2016; Mook et al., 1980; Renwick, 1985, 1986; Sclafani and Nissenbaum, 1985) and unlike sucrose, saccharin meal size and meal frequency are controlled primarily by oropharyngeal satiety (Kushner and Mook, 1984; Mook et al., 1980, 1981; Renwick, 1985, 1986; Sclafani and Nissenbaum, 1985). Nonetheless, the possibility remains that dHC inhibition disrupts saccharin intake by interfering with the processing of any mechanical stimulation produced by the saccharin solution in the gut (Waise et al., 2018).

  • Postmeal optogenetic inhibition of dorsal hippocampal principal neurons increases future intake in a time-dependent manner

    2021, Neurobiology of Learning and Memory
    Citation Excerpt :

    We used an optogenetic approach to test the prediction that postmeal inhibition increases subsequent intake when given after the end of a meal and that delayed inhibition has no effect. A saccharin solution served as the meal in the present experiment because it has minimal postingestive gastric consequences (Foletto et al., 2016; Mook, Bryner, Rainey, & Wall, 1980; Renwick, 1985, 1986; Sclafani & Nissenbaum, 1985), which diminished the possibility that any time-dependent effects of postmeal inhibition could be due to the timing of interoceptive visceral cues generated by the meal. Adult male Sprague-Dawley rats (8–10 weeks old; N = 15; Charles River Laboratories) were housed singly under a 12:12 hr light–dark cycle and given ad libitum access to pelleted food and water.

  • Cognitive control of meal onset and meal size: Role of dorsal hippocampal-dependent episodic memory

    2016, Physiology and Behavior
    Citation Excerpt :

    As in our previous experiment, rats were trained to consume a sucrose solution at the same time and place daily. We also tested the effects of an isopreferred concentration of saccharin, which produces similar orosensory stimulation to sucrose but does not result in any significant postingestive effects [115–119]. On the experimental day, the rats were given a solution for 7 min, euthanized, and then FISH procedures were used to measure Arc mRNA expression.

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*

This research was supported by PHS Grant No. MH 10766. We thank Carol Lynn Cseh for technical assistance, and John F. Hahn for his comments on a preliminary version of the manuscript.

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