100 years of nissl staining

doi:10.1016/S0166-2236(84)80213-1

Trends in Neurosciences

Volume 7, Issue 7, July 1984, Pages 236-237

https://doi.org/10.1016/S0166-2236(84)80213-1 Get rights and content

100 years ago a student introduced alcohol fixation and basic aniline dyes into neurohistology. He thus opened up a new era in neurocytology and made microscopical neuropathology possible. Even today the Nissl stain is the most common histological preparation in use.

Reading list (7)

NisslF.
FlemmingW.
Zellsubstanz Kern und Kernteilung
(1882)
NisslF.
de
Neurol. Centralblatt
(1894)

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Transauricular Vagal Nerve Stimulation at 40 Hz Inhibits Hippocampal P2X7R/NLRP3/Caspase-1 Signaling and Improves Spatial Learning and Memory in 6-Month-Old APP/PS1 Mice
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Citation Excerpt :
This might indicate that 40-Hz taVNS promotes neurogenesis in the DG of 6-month-old APP/PS1 mice. Nissl staining was used to detect neuronal morphologic integrity.62,65 Compared with the APP/PS1 group, hippocampal neurons in the APP/PS1 + 40-Hz taVNS group were arranged more neatly, with darker and more obvious Nissl bodies (Fig. 5c).
Transauricular vagal nerve stimulation (taVNS) at 40 Hz attenuates hippocampal amyloid load in 6-month-old amyloid precursor protein/presenilin 1 (APP/PS1) transgenic mice, but it is unclear whether 40-Hz taVNS can improve cognition in these mice. Moreover, the underlying mechanisms are still unclear.
6-month-old C57BL/6 (wild type [WT]) and APP/PS1 mice were subjected to 40-Hz taVNS. Novel Object Recognition and the Morris Water Maze were used to evaluate cognition. Hippocampal amyloid-β (Aβ)1-40, Aβ1-42, pro–interleukin (IL)-1β, and pro–IL-18 were measured using enzyme-linked immunosorbent assays. Hippocampal Aβ42, purinergic 2X7 receptor (P2X7R), nucleotide-binding oligomerization domain–like receptor pyrin domain containing 3 (NLRP3), Caspase-1, IL-1β, and IL-18 expression were evaluated by western blotting. Histologic assessments including immunofluorescence, immunohistochemistry, Nissl staining, and Congo red staining were used to assess microglial phagocytosis, neuroprotective effects, and Aβ plaque load.
40-Hz taVNS improved spatial memory and learning in 6-month-old APP/PS1 mice but did not affect recognition memory. There were no effects on the cognitive behaviors of 6-month-old WT mice. taVNS at 40 Hz modulated microglia; significantly decreased levels of Aβ1-40, Aβ1-42, pro–IL-1β, and pro–IL-18; inhibited Aβ42, P2X7R, NLRP3, Caspase-1, IL-1β, and IL-18 expression; reduced Aβ deposits; and had neuroprotective effects in the hippocampus of 6-month-old APP/PS1 mice. These changes were not observed in 6-month-old WT mice.
Our results show that 40-Hz taVNS inhibits the hippocampal P2X7R/NLRP3/Caspase-1 signaling and improves spatial learning and memory in 6-month-old APP/PS1 mice.
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Trends in Neurosciences

Reading list (7)

Zellsubstanz Kern und Kernteilung

de

Neurol. Centralblatt

Cited by (11)

Transauricular Vagal Nerve Stimulation at 40 Hz Inhibits Hippocampal P2X7R/NLRP3/Caspase-1 Signaling and Improves Spatial Learning and Memory in 6-Month-Old APP/PS1 Mice

Alois Alzheimer

Cholesterol-24-hydroxylase (CYP46) in the old brain: Analysis of positive populations and factors triggering its expression in astrocytes

Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

Constructing the rodent stereotaxic brain atlas: a survey

Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

Trends in Neurosciences

Perspective100 years of nissl staining

Zellsubstanz Kern und Kernteilung

de

Neurol. Centralblatt

Perspective
100 years of nissl staining