Research reportEpilepsy and hormonal regulation: the patterns of GnRH and galanin immunoreactivity in the hypothalamus of epileptic female rats
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Mechanisms linking neurological disorders with reproductive endocrine dysfunction: Insights from epilepsy research
2023, Frontiers in NeuroendocrinologyFemale-specific pituitary gonadotrope dysregulation in mice with chronic focal epilepsy
2023, Experimental NeurologyPhenotypic differences based on lateralization of intrahippocampal kainic acid injection in female mice
2022, Experimental NeurologyCitation Excerpt :In a previous study, decreased progesterone was observed at 2 months after injection in IHKA-R mice with long cycles (≥ 7-day cycle period), and IHKA-R mice with both long and regular cycles (4- to 6-day period) lacked the decrease in estradiol levels on estrus compared to diestrus seen in controls (Li et al., 2018). Furthermore, altered serum levels of these hormones have been reported in other rodent models of TLE that also display cycle disruption (Amado et al., 1993; Scharfman et al., 2008). Therefore, the trunk blood serum of IHKA-L, IHKA-R, Con-L, and Con-R mice collected on diestrus at 1, 2, and 4 months post-injection was analyzed through ELISA for levels of estradiol, progesterone, and testosterone.
Epilepsy and exercise: An experimental study in female rats
2017, Physiology and BehaviorCitation Excerpt :Following the first spontaneous seizure, animals presented a diminution in proestrus and estrus phases and an increased diestrus phase, thereby characterizing an increase in anovulatory cycles. During the first period, we observed this similar profile of the estrous cycle for all groups with epilepsy which accords with previous studies by our group [21,22]. However, in the second period, the profile of the estrous cycle in the voluntary exercise group altered, becoming more similar to that observed in healthy animals, with a decreased diestrus phase and discrete increase (not significant) in other phases.