Neuron
ArticleDesensitization of AMPA receptors upon multiquantal neurotransmitter release
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2022, Cell ReportsCitation Excerpt :However, these effects are unable to explain the differences we observed in the PPR since neither passive property was significantly correlated with the PPR (Spearman correlation, cell capacitance versus 50 ms ISI PPR, R2 = 0.015, p = 0.25; input resistance versus 50 ms ISI PPR, R2 = 0.005, p = 0.49). Postsynaptic AMPA receptor desensitization can also contribute to the PPR,38 but blocking this process with 100 μM cyclothiazide increased response amplitudes without altering the 50 ms PPR (Figures S3A–S3C), and these effects were no different between control and 2 week post-MMZ slices (Figures S3B and S3C; percentage of first peak amplitude, PBS, mean ± SEM, 136.2% ± 8.2%, n = 13 cells, N = 9 mice; MMZ [2 weeks], 119% ± 4.2%, n = 10, N = 9; unpaired t test with Welch’s correction, t17.5 = 1.87, p = 0.079; percentage of 50 ms ISI PPR, PBS, 104.5% ± 4.1%, n = 13, N = 9; MMZ [2 weeks], 109.1% ± 3.1%, n = 10, N = 9; unpaired t test with Welch’s correction, t20.6 = 0.89, p = 0.38). PPRs at OSN terminals can also be influenced by presynaptic inhibition via GABAB and D2 signaling,24,26 so we compared 50 and 500 ms PPR values in baseline artificial cerebrospinal fluid (aCSF) versus aCSF containing antagonists for both receptors (Figures S3D–S3G).
Synaptic plasticity in schizophrenia pathophysiology
2022, IBRO Neuroscience Reports