ArticleGlutamate and dynorphin release from a subcellular fraction enriched in hippocampal mossy fiber synaptosomes☆
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2016, Journal of Chemical NeuroanatomyCitation Excerpt :However, it has been demonstrated that the granule cells produce and release the two most abundant excitatory and inhibitory amino acids for fast neurotransmission, respectively: glutamate (Crawford and Connor, 1973; Storm-Mathisen, 1981; Storm-Mathisen et al., 1983) and GABA (see below). Studies carried out on MF synaptosomes provided the first neurochemical evidence showing that MF terminals contained and released GABA (Terrian et al., 1988; Taupin et al., 1994a,b). Sandler and Smith (1991) found GABA immunoreactivity in MF terminals that made asymmetric synaptic contact with spines arising from large dendrites of CA3 pyramidal cells of monkey and human hippocampi.
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2007, Progress in Brain ResearchCitation Excerpt :The most prominent are those of peptidic nature, which are contained and released from large dense-core vesicles. Dynorphin and enkephalin, as well as their receptors, are present in the MFs in rodents and humans, but there is variation between mammalian species (Gall et al., 1981; McGinty et al., 1983; Chavkin et al., 1985; McLean et al., 1987; Terrian et al., 1988; Houser et al., 1990; Chavkin, 2000). The actions of opioid peptides in the hippocampus are inhibitory, mediated by inhibition of Ca++ currents, in the case of dynorphin, or activation of K+ currents, in the case of enkephalins, and are a consequence of activation of G-protein-coupled receptors (Zieglgänsberger et al., 1979).
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The animals involved in this study were procured, maintained and used in accordance with the Animal Welfare Act and the “Guide for the Care and Use of Laboratory Animals” prepared by the Institute of Laboratory Animal Resources—National Research Council.