Olfactory disturbance induced by deafferentation of serotonergic fibers in the olfactory bulb
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Cited by (49)
Olfactory disturbances in Parkinson’s disease
2020, Genetics, Neurology, Behavior, and Diet in Parkinson’s Disease: The Neuroscience of Parkinson’s Disease, Volume 2Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate?
2017, The Lancet NeurologyCitation Excerpt :Despite age-related deficits in smell and sleep, no age-related changes are apparent in the proportion of cells that are able to synthesise serotonin in the medial raphe nuclei.60 Nevertheless, one study61 reported smell loss in rats within a few weeks after lesioning serotonergic projections to the olfactory bulb with the serotonergic neurotoxin 5,7-DHT. Noradrenergic fibres were spared but glomerular dopaminergic neurons were not, and the olfactory receptor cell population was markedly reduced, reflecting atrophy within the granule and the internal and external plexiform layers.
The Olfactory System
2015, The Rat Nervous System: Fourth EditionOlfaction in Parkinson's disease and related disorders
2012, Neurobiology of DiseaseCitation Excerpt :Many neurons of the olfactory system, particularly those within the microglia-rich olfactory bulb, have high metabolic activity and reduced antioxidant capacity, making them susceptible to impairment of mitochondrial function, oxidative stress, and excitotoxicity. The observation that toxic damage to serotonergic neurons that enter the bulb produces anosmia and marked atrophy of all layers of the bulb strongly suggests that 5-HT input is essential for maintaining the integrity of the bulb and, in particular, dopaminergic neurons (Moriizumi et al., 1994; Tsukatani et al., 1995). Drugs that inhibit the 5-HT transporter are known to induce microglial activation and damage to dopaminergic neurons within the substantia nigra (Macgillivray et al., 2011).
Functional correlation between olfaction and various sectioning of the lateral olfactory tract
2012, Neuroscience ResearchCitation Excerpt :For this purpose, after direct visualization of the LOT, we made sharp transections on the LOT at different levels between the olfactory bulb and the middle cerebral artery. After removal of the olfactory bulb contralateral to the injured LOT, olfactory function was examined in the LOT-transected rats by their olfactory ability to discriminate between the smell of water and cycloheximide solution, a strong repellent for rodents (Fukushima et al., 2002; Moriizumi et al., 1994; Sakamoto et al., 2010). An anterograde neuronal tracing method was employed to confirm completeness of LOT transection and to exclude incomplete LOT-transected animals.