Selective degeneration by capsaicin of a subpopulation of primary sensory neurons in the adult rat
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Cited by (207)
Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain
2021, Pharmacology and TherapeuticsRole of capsaicin sensitive sensory nerves in ischemia reperfusion-induced acute kidney injury in rats
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In this study, although capsaicin can directly act on adult rats resulting in selective degeneration of primary sensory neurons, SD neonatal rats were chosen to take capsaicin treatment for denervation of afferent sensory nerves. The reason is that capsaicin given to newborn rats would result in an irreversible loss of specific sensory functions, with a greater proportion reduction in the numbers of dorsal root ganglion neurons and unmyelinated axons, as compared with that of adult rats taking such treatment [25,26]. There are also other methods to achieve renal denervation.
Sensory denervation of inguinal white fat modifies sympathetic outflow to white and brown fat in Siberian hamsters
2018, Physiology and BehaviorCitation Excerpt :We measured NETO in WAT depots and IBAT of hamsters that had IWAT sensory denervation using CAP, the pungent component of red chili peppers. CAP chemically destroys sensory nerves and is more specific than surgical denervation where both SNS or sensory nerves are likely to be severed due to their close proximity to each other [30,34,35,44,45]. Unchanged TH staining in CAP injected WAT verified CAP's specificity for destroying afferents [35,46].
Analysis and measurement of the sympathetic and sensory innervation of white and brown adipose tissue
2014, Methods in EnzymologyMechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na<sup>+</sup>/Ca<sup>2+</sup> fluxes and the Ca<sup>2+</sup>-binding protein calretinin
2013, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Depending on the concentration applied and the exposure time, TRPV1 agonists cause either desensitization [21] or selective degeneration of a distinct population of primary sensory neurons involved in the mediation of pain [22]. Systemic administration of CAPS results in the death of approximately 50% of sensory neurons in rat neonates [13] and in a loss of approximately 17% in adult rats [23]. RTX, an ultrapotent CAPS analogue, almost completely eliminates TRPV1-expressing afferent neurons in adult rats, when applied systemically [24].
Tachykinin (NK1, NK2 and NK3) receptor, transient receptor potential vanilloid 1 (TRPV1) and early transcription factor, cFOS, mRNA expression in rat tissues following systemic capsaicin treatment
2013, Regulatory PeptidesCitation Excerpt :No significant changes in the brain stem and frontal cortex message were apparent. The original studies of Jancso and colleagues [26] reported degeneration of ~ 30% of sensory neurons in the rat saphenous nerve at the dose employed in the present study. Whilst degeneration may have contributed in part to the changes that we observed, one would have expected consistent changes in tachykinin receptor and TRPV1 mRNA expression in tissues known to be supplied by capsaicin-sensitive neurons.