Relationship of age-related decline across several behavioral domains
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2019, Neurobiology of AgingCitation Excerpt :Similar results were found for scanning rate (Fig. 2E) [2W-ANOVA, condition: F(1,26) = 12.825, p = 0.001; age: F(1,26) = 0.015, p = 0.904; condition × age: F(1,26) = 0.286, p = 0.597; Paired t-test: Y NC p = 0.482, Y DR 0.028; AU NC p = 0.905, AU DR p = 0.001) (Fig. 2F). Altogether, these data show that AU rats responded similarly to young rats during training and test, consistent with other studies demonstrating intact information processing and memory function in aged rats behaviorally characterized as unimpaired in this study population (Gallagher and Burwell, 1989; Haberman et al., 2013; Pereira et al., 2015; Robitsek et al., 2008). The equivalent behavioral response in this cue mismatch paradigm provides a basis to compare hippocampal gene expression signatures between Y and AU.
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