Research reportMolecular characterization and localization of human metabotropic glutamate receptor type 4☆
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Cited by (47)
The developmental expression of metabotropic glutamate receptor 4 in prenatal human frontal lobe and neurogenesis regions
2019, Brain and DevelopmentCitation Excerpt :A growing body of evidence suggests that mGluR4 is expressed in postnatal rodent or human brain. The mRNA and protein expression for mGluR4 could be detected at birth, then increase gradually and in adult preferentially express in cerebellum, hippocampus, basal ganglia and thalamus, etc [27–31]. However, so far the data about the expression of mGluR4 in prenatal brain are very hard to be found.
Regulation of the brain-gut axis by group III metabotropic glutamate receptors
2013, European Journal of PharmacologyCitation Excerpt :Here we present a summary of the localisation of group III mGlu receptors within the CNS. mGlu4 receptor is expressed in cerebellum, olfactory bulb, entorhinal cortex, globus pallidus, substantia nigra, hippocampus, lateral septum, amygdala, striatum, dorsal horn, retina, nucleus tractus solitarius in the medulla oblongata and in pontine, thalamic and mammillary nuclei (Bradley et al., 1996; Corti et al., 2002; Ferraguti and Shigemoto, 2006; Kinoshita et al., 1996; Makoff et al., 1996; Ohishi et al., 1995). Although mGlu4 receptor is mostly located presynaptically, it has also been found postsynaptically in hippocampal neurons (Bradley et al., 1996).
Positive allosteric modulation of metabotropic glutamate 4 (mGlu4) receptors enhances spontaneous and evoked absence seizures
2008, NeuropharmacologyCitation Excerpt :This suggests that the regulation of absence seizures by mGlu4 receptors is mainly exerted at the level of RTN (see below). High mGlu4 receptor mRNA and protein levels are found in rodent and human thalamic relay nuclei (Ohishi et al., 1995; Makoff et al., 1996; Thomsen and Hampson, 1999; Lourenco Neto et al., 2000; Corti et al., 2002), whereas low mRNA and low-to-moderate mGlu4 protein levels are found in primary somatosensory cortex, and, particularly, in the outer cortical layers (Ohishi et al., 1995; Corti et al., 2002). Because no mGlu4 receptor mRNA is detectable in the RTN (Ohishi et al., 1995; Lourenco Neto et al., 2000; Shigemoto and Mizuno, 2000; and present data), the mGlu4 receptor protein found in the RTN must be present on extrinsic inputs.
Mglu4 metabotropic glutamate receptor
2007, xPharm: The Comprehensive Pharmacology ReferenceChapter III Metabotropic glutamate receptors - immunocytochemical and in situ hybridization analyses
2000, Handbook of Chemical Neuroanatomy
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The nucleotide sequence reported in this paper has been submitted to the EMBL Data Bank with accession number X80818.