Myelin localization of a central nervous system ligand for L-selectin
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Cited by (24)
Association between soluble L-selectin and anti-JCV antibodies in natalizumab-treated relapsing-remitting MS patients
2015, Multiple Sclerosis and Related DisordersCitation Excerpt :Role of L-selectin in MS pathogenesis has been studied earlier. Different studies have shown that l-selectin is involved in myelin damage processes in the CNS (Grewal et al., 2001; Huang et al., 1994). l-selectin is constitutively expressed on lymphocytes, and it mediates the initial capturing and tethering of leukocytes to the endothelium.
Lymphotoxin-β receptor signaling is required for the homeostatic control of HEV differentiation and function
2005, ImmunityCitation Excerpt :Not all ectopic sites exhibit this level of structure, yet even in the absence of distinct B cell follicles, HEV can be observed (van Dinther-Janssen et al., 1990; Yoneyama et al., 2001). It will be interesting to see whether addressin expression is affected in nonendothelial sites, e.g., MAdCAM on the inflamed choroid plexus in the brain or perhaps the L-selectin ligands in CNS Myelin (Huang et al., 1994; Wolburg et al., 1999). Ectopically expressed addressins could facilitate entry of effector T cells, B cells, and plasma cells into inflamed sites, and therefore elimination of this entry portal may be therapeutically useful.
The Selectins and their Ligands. Adhesion Molecules of the Vasculature
1999, Advances in Molecular and Cell BiologyRole of the leukocyte-adhesion molecule L-selectin in experimental autoimmune encephalomyelitis
1998, Journal of the Neurological Sciences
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