Research paperChronic drug infusion into the scala tympani of the guinea pig cochlea
References (20)
- et al.
Components of cochlear electric responses in the alligator lizard
Hear Res.
(1983) - et al.
Volume flow rate of perilymph in the guinea pig cochlea
Hear Res.
(1988) - et al.
Afferent influences on brain stem auditory nuclei of the chicken: presynaptic action potentials regulate protein synthesis in nucleus magnocellularis neurons
J Neurosci.
(1988) - et al.
Effect of pentobarbital anesthesia on amikacin concentrations in plasma and perilymph and evaluation of multiple sampling in perilymph of guinea pigs
Antimicrob. Agents Chemother.
(1985) - et al.
Development of pressure monitoring and controlling system for quantitative analysis of experimentally induced perilymph fistula
Acta Otolaryngol.
(1988) - et al.
The effects of prenatal intracranial infusion of tetrodotoxin on naturally occurring retinal ganglion cell death and optic nerve ultrastructure
Eur. J. Neurosci.
(1990) - et al.
Long-term morphological and electrophysiological effects of small mechanical lesions in the guinea pig cochlea
Acta Otolaryngol.
(1974) - et al.
Cochlear ototoxicity of chlorhexidine gluconate in cats
Arch. Otorhinolaryngol.
(1985) - et al.
The effect of tetrodotoxin on electrically induced damage in the cochlea
(1991) - et al.
Round window membrane permeability: an in vitro model
Acta Otolaryngol.
(1987)
Cited by (34)
Round window membrane intracochlear drug delivery enhanced by induced advection
2014, Journal of Controlled ReleaseCitation Excerpt :However, drug delivery to the inner ear is challenging due to its small size and anatomical location in the temporal bone. Intra-cochlear delivery of drugs or genes has been successfully accomplished in animal models by injection through the round window membrane [4], injection into the endolymphatic space via scala media [5,6] and endolymphatic sac [7], and injection or infusion into the perilymphatic space via the semicircular canals [8], scala vestibuli [9,10], and most commonly the scala tympani [11–13]. Drug delivery is generally accomplished via a syringe pump [14] or an osmotic pump [15] for continuous infusion, or a reciprocating pump for zero net volume delivery [16].
Ultrasound-aided microbubbles facilitate the delivery of drugs to the inner ear via the round window membrane
2013, Journal of Controlled ReleaseCitation Excerpt :Methods for local delivery can include intratympanic or intracochlear approaches. Intracochlear drug delivery is achieved via a cochleostomy through the round window membrane (RWM) or directly through the otic capsule, and a variety of devices, including syringe [1], osmotic pumps [4], microinjector [5], and a reciprocating drug delivery system [6], have been employed. Although intracochlear application can achieve greater bioavailability of drugs entering the inner ear than the intratympanic approach, the former usually requires invasive surgical manipulation to interrupt the inner ear structure, and may increase the risk of deafness [3].
Murine intracochlear drug delivery: Reducing concentration gradients within the cochlea
2010, Hearing ResearchCitation Excerpt :Insertion depths of 102, 127, 153, and 178 μm were created on micro drills of 175 μm and 100 μm diameters. The use of silicone insertion stops on the infusion tubing has been reported in the literature to limit the depth of penetration (Kingma et al., 1992; Chen et al., 2006; Johnson et al., 2007). For the present study, more effective seals were produced by direct bonding to the polyimide cannulae without insertion stops, so the stops were not used.
Inner ear drug delivery for auditory applications
2008, Advanced Drug Delivery ReviewsLocalized cell and drug delivery for auditory prostheses
2008, Hearing ResearchInner ear drug delivery via a reciprocating perfusion system in the guinea pig
2005, Journal of Controlled Release
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