Cell
Volume 79, Issue 1, 7 October 1994, Pages 49-58
Journal home page for Cell

Article
Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

https://doi.org/10.1016/0092-8674(94)90399-9Get rights and content

Abstract

Consolidated memory after olfactory learning in Drosophila consists of two components, a cycloheximide-sensitive, long-term memory (LTM) and a cycloheximide-insensitive, anesthesia-resistant memory (ARM). Using an inducible transgene that expresses a dominant negative member of the fly CREB family, LTM was specifically and completely blocked only after induction, while ARM and learning were unaffected. These results suggest that LTM formation requires de novo gene expression probably mediated by CREB family genes.

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